シンポジウム3．
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
慢性骨髄増殖性疾患およびその周辺疾患の病理
1988 年 29 巻 7 号 p. 969-976
詳細
1988 年 29 巻 7 号 p. 969-976
In order to clarify the relationship among various types of myeloproliferative disorders (MPD), 58 autopsy cases and 27 autopsy cases of related diseases were examined histologically, immunohistochemically and morphometrically. In chronic type of MPD, chronic myelocytic leukemia (CML), polycythemia vera (PV), myelofibrosis (MF) and essential thrombocythemia (ET), mainly proliferating cells were recognized; granulocyte lineage in CML, erythrocyte lineage in PV, granulocyte lineage and fibroblasts in MF and thrombocyte lineage in ET. However, these differences in proliferating cell type of MPD were not essential but quantative, various type of cell lineages were recognized in each type of MPD. Especially fibrosis was not essential to MF and were found in other MPD. Each transition in MPD were also observed. These findings would indicate that various types of MPD are closely related disorders, having mainly proliferating cell lineage. Immunohistochemial method with various specific antibodies were useful for recognition of various cell lineages.
