シンポジウム3．
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
慢性骨髄増殖性症候群―各疾患相互の関係と位置づけ―
in vitro hematopoiesisよりみた慢性骨髄増殖性疾患の検討
（CML marrow stromal cellの由来と機能）
1988 年 29 巻 7 号 p. 994-1000
詳細
1988 年 29 巻 7 号 p. 994-1000
Chronic myeloproliferative syndromes are disorders originating from multipotent stem cells. Marrow stromal cells, which are defined as the major component of hematopoietic microenvironment, were demonstrated to be different from fibroblasts in the aspects of collagen synthesis, reactivity to the monoclonal antibodies against actin, and the function of stimulating granulopoiesis. Over 95% of marrow stromal cells established from sex mismatched marrow transplanted patients later than 45 days posttransplant were donor origin by the Y-body analysis. Marrow stromal cells established from G6PD heterozygous CML patients were demonstrated to be clonaly involved by the analysis of G6PD isoenzymes. In addition, SV40-transformed cells in marrow adherent cell layer were shown to be able to give rise to both hematopoietic and adherent stromal cells. These findings suggested that chronic myeloproliferative syndromes including CML are clonal hemopathies originating from immature stem cells which can give rise to hematopoietic and stromal cells.
