抄録
We studied a clinical analysis of the cases with acute megakaryoblastic leukemia (M7 of FAB classification of acute leukemia) in Japan. Twenty six cases of M7 and 6 of “acute myelofibrosis (AMF)” were reported in questionnaires. Twenty one cases of M7 were treated with antileukemic chemotherapy and 47.6% of them achieved complete remmission with a median survival of 12 mos. The effective chemotherapy was myeloid defined regimen such as a combination with anthracycline, cytosine arabinoside and 6MP. None of 3 cases with AMF receiving treatment responded to antileukemic chemotherapy. Complete remmision rate was lower in the M7 cases with myelofibrosis than in those without myelofibrosis. Some cases with M7 had a long pretreatment duration and their complete remmision rate was lower than the other M7 cases, indicating that their clinical courses ressembled those of 4 cases with “AMF” having rather prolonged courses. It is suggested that these cases might be similar to myelodysplasia with myelofibrosis.
