短報
Methylprednisolone pulse療法およびrhG-CSF投与により改善したstreptomycinが原因と考えられた重症型再生不良性貧血
1993 年 34 巻 11 号 p. 1491-1493
詳細
1993 年 34 巻 11 号 p. 1491-1493
An 83-year-old male was admitted with pulmonary tuberculosis. He was started on rifampicin, isoniazid, and stereptomycin (SM). The hematological data at 12 weeks after the treatment showed pancytopenia (RBC: 2.14×106/μl, Hb: 7.2g/dl, Plt: 1.8×104/μl, WBC: 700/μl). All the above medicines were discontinued and he received bolus methylprednisolone (bmPSL) and recombinant human granulocyte-colony stimulating factor (rhG-CSF). After 3 cycles of bmPSL, red blood cells and platelets gradually increased. White blood cells also increased in response to rhG-CSF. Bone marrow aspirate and biopsy specimens showed normocellularity, indicating recovery from aplastic anemia. Drug lymphocyte stimulation test was positive for SM.
