抄録
The fibrinolytic activity, the antifibrinolytic effect of trans-4-Aminomethylcyclohexane -1- Carboxylic acid (trans-AMCHA or Transamin), known as antiplasmin were evaluated from surgical view-point. Results obtained were as follows:
1) Higher level was observed in uterine cancer and gastric cancer at preoperative period, compared, with that of tympanoplasty.
2) Pre-medication which was consisted of pentobarbital, phenothiazine, atropine and meperidine, which caused the decrease of fibrinolytic activity.
3) Compared with that of pre-and post-operative periods, the fibrino-lytic activity during surgery, measured by SK-activation method was slight, but those measured by α-CT-activation method resulted in a marked increase.
4) Administering trans-AMCHA during surgery the fibrinolytic activity were suppressed remarkably than that of pre-operative level by SK-activation method, but they were scarcely suppressed, while that of pre-operative level by α-CT-activation method did remarkably.
5) An increase of fibrinolytic activity following blood transfusion is explained by physical and chemical reactions which will result from the stimulation of transfusion and by the surgical stress itself.
6) There was no untoward-side effect caused by trans-AMCHA during general anesthesia.
