抄録
Serial Thrombin Time (STT) Method which does not need any particular skill in the procedure is very practical for the evaluation of circulating plasmin activity. But there have been only a few informations of basic studies on STT, and very few invenstigators have used this method in daily practice.
We evaluated Reid's method adding some modification to it, developed new one, and then performed in vitro and in vivo investigations by the latter.
STT determinations were carried out upon patients with various diseases and they were compared with the results by other methods for fibrinolytic activity, such as Euglobulin Lysis Time (Eug. L.T.) and Hemagglutination Inhibition Titer (HIT) which is used for estmating fibrinogen breakdown products.
Results: (1) The prolongation of STT was regarded as the result of the minimal increase in plasmin activity which is not enough for giving a change in the plasma fibrinogen concentration and for lysis of the standard bovine fibrin plate. (2) Prolonged STT was observed in chronic hepatitis, cirrhosis of the liver, malignant neoplasms, and in myocardial infarction. (3) STT demonstrated the minimal increase in fibrinolytic activity which could not be detected by Eug. L.T.. (4) About 88% of increased fibrinolytic activity detected by STT-30' showed abnormal rises in HIT. (5) Dynamically determined STT-30' in a patient administered urokinase went in parallel with Eug. L.T.. (6) STT in a patient with disseminated cancer of the stomach went in parallel with the bleeding tendency.
