抄録
White blood cell count (WBC) serves as an index of infectious diseases and inflammatory diseases. Inflammation of the blood vessel diverges into thrombosis, coronary arteritis, Kawasaki disease, vasculitis, and other diseases. It is associated with infectious diseases and the activation of the fibrinolysis system, associated with an increase of WBC: lymphocytes, macrophages, neutrophils, eosinophils, and basophils. It demonstrated that the engagement of neutrophilic activity contributed to the formation of aneurysms of the risky factor of Kawasaki disease during the era of 1982. The neutrophil counts in the peripheral blood of patients with Kawasaki disease increased prior to a rise of platelets counts, immediately preceding the onset of aneurysms formation. It was confirmed that myeloperoxidase (MPO)-release activity from adherent neutrophils in the patients during the subsequent disease period. Similar observations were reported in cases of microscopic polyangiitis (MPA). These observations are found within peripheral blood. Furthermore, the activated neutrophils in patients with various kinds of diseases release neutrophil extracellular traps (Nets), mainly observed in peripheral blood occasionally extending into tissues. Typically, we have observed the presence of inflammatory neutrophils in sputum fluid and urine; however, a thorough examination of their functional attributes remains unexplored. Therefore, it is important that normal neutrophils are distinguished from activated neutrophils in peripheral blood in order to establish an index of disease activity pertaining to Fulminant neutrophils. They are different from normal neutrophils counted as WBC.
https://ror.org/001ggbx22 
