日本放線菌学会誌
Online ISSN : 1881-6371
Print ISSN : 0914-5818
ISSN-L : 0914-5818
Proceedings of the Workshop Micro Alchemists, “Actinomycetes”
New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces
Shinobu KagamiKen-ichi KimuraYoshikazu IkedaHidetoshi TakahashiHiroo KusakabeHiroyuki OsadaKiyoshi IsonoMakoto Yoshihama
著者情報
ジャーナル フリー

1998 年 12 巻 2 号 p. 110-119

詳細
抄録
Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a Streptomyces sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Liposidomycins which have no sulfate moiety, exhibited more potent antimicrobial activity. Thus liposidomycins are the unique antibiotics showing highly specific inhibition toward bacterial peptidoglycan synthesis and could be a useful clinical antibiotic agent.
著者関連情報
© 1998 The Society for Actinomycetes Japan
前の記事 次の記事
feedback
Top