抄録
Fosfomycin (FM, Fig. 1) is a medically important antibiotic produced by various species of Streptomyces1) as well as Pseudomonas syringae PB-51232) and Ps. viridiflava PK-53). FM is characterized by unique structural functions such as a carbon-phosphorus (C-P) bond and an epoxide4). Acting as an analog of phosphoenolpyruvate, it irreversibly inhibits phosphoenolpyruvate UDP-N-acetylglucosamine-3-O-enolpyruvyltransferase (enolpyruvyltransferase), the enzyme that catalyzes the first step of peptidoglycan biosynthesis, and shows almost no toxicity to humans5). We review here FM biosynthesis and self-resistance, and the biosynthetic genes in S. wedmorensis.
