抄録
Terrestrial Actinobacteria have served as a primary source of bioactive compounds. However, a rapid reduction in the discovery of new compounds strongly necessitates new investigational approaches, including screening Actinobacteria from marine habitats. We therefore studied and compared the diversity of culturable Actinobacteria associated with 18 marine sponge samples. A total of 462 strains of Actinobacteria belonging to 19 genera were isolated; 24 of these strains represented new species in six genera. Only 28 strains showed seawater-dependent growth. Eleven strains belonging to the genera Streptomyces (8 strains), Rhodococcus (2), and Nocardiopsis (1) required ≥50% (v/v) seawater for their growth, whereas an additional 17 strains showed better growth in the presence of 50% seawater (v/v). Screening of strains for antimicrobial activity showed that 144, 24, and 77 strains exhibited activity against Micrococcus luteus, Escherichia coli, and Candida albicans, respectively.
