ヒト妊娠初期壁, 基底および被包脱落膜の形態ならびにプロラクチン産生能に関する研究

抄録

The ultrastructure and prolactin production of the decidua parietalis, basalis, and capsularis at 6, 10, and 14 weeks of normal pregnancy were studied. Using five ultrastructural characters, the decidual cells were classified into three types. Type I cell had few organelles and resembled fibroblast. Type II cell possessed many organelles and produced osmiophilic substance in rough endoplasmic reticulum. Type III cell showed typical peduncular processes, usually contained secretary granules. The prolactin concentrations in the medium of the organ culture for 48 hours were determined by radioimmunoassay.
In the decidua capsularis, Type III cells were the most in number at 6 weeks of gestation and the cytoplasmic organella of those were the most abundant at 10 weeks of gestation. By 14 weeks of gestation, the ultrastructural evidence of cellular activity began to decline. The proportin of Type III cells in the decidua parietalis had a tendency to increase as the gestational age progressed. In all weeks of gestations, Type I cells were observed more frequently in the decidua basalis than other portions, and the stromal cells seemed to maturate slowly on that portion.
The decidua parietalis released large amounts of prolactin compared with other portions of decidua (p < 0.05). The amount of prolactin synthesis was related to the distribution of Type I, II, and III cells. These results suggest that the decidua of each portion in the uterus during early gestation has different ratios of the 3 cell types and that the decidua parietalis could be a main source of amniotic fluid prolactin. [Adv Obster Gynecol 47(2) : 277-286, 1995 (H7.3)]