IgG型M-蛋白血症患者血清の免疫電気泳動における正常IgG出現の機序

抄録

A residual IgG line is frequently observed inside the monoclonal IgG line on immunoelectrophoresis of IgG myeloma serum in reaction with anti-whole human serum. We found that the residual IgG line was observed exclusively in serum from IgG-λ type M-proteinemia when a goat antiserum to whole human serum was employed. However, with a horse antiserum to whole human serum, the residual IgG line was observed in sera from both the IgG-λ and κ type M-proteinemias. These phenomena led us to an idea that the appearance of the residual IgG line resulted from reaction with anti-κ or λ antibodies present in the anti-whole human serum antisera. Investigations of sera from a number of IgG M-proteinemia by anti-κ and λ antisera, and absorption tests with partially purified BJP of both types indicated that the occurrence of the residual IgG line is due to the reaction of polyclonal IgG with anti-κ or λ chain antibody present in the anti-whole human serum.