On August 8, 1967, the Japanese Ministry of Public Welfare announced the list of the ingredients which were authorized to be available in its cosmetic industry, in which 4 types of Kankoh-so, namely No. 101, 201, 301 and 401 are involved as the authorized materials. We made our utmost efforts in research, production and application of these materials in order to improve these substances in many directions and succeeded in creating some new derivatives from them. These new derivatives have almost the same physiological actions with the original Kankoh-so, however, have fairly low toxity and better solubilities in several solvents than the originals.
In this paper, their synthesizing method, physical properties and medical researches were described in detail. We believe that the new derivatives are more favourable as cosmetic ingredients.