ヒト角層中の遊離アミノ酸の挙動

抄録

There are many reports relating to the differences of free amino acids between abnormal skin and normal one, however their relations remain still unclear.
The behaviors of free amino acids in the stratum corneum of normal epidermis and abnormal one which was artifically induced by UV-irradiation and application of surfactant were examined.
Free amino acids in the stratum corneum of epidermis changed with region of body, seasons and ages. Especially citrulline and ornithine showed characteristic behaviors. It was suggested that citrulline and ornithine were related with each other.
By UV-irradiation and application of surfactant, the amounts and composition of free amino acids were changed. The behaviors of changes were the same in both cases; citrulline and ornithine were characteristic.
These phenomena suggested that free amino acids in the stratum corneum reflected the epidermal keratinization. By analysis of free amino acids extracted from the human skin, useful informations relating to skin conditions will be offered.