活性酸素によるヒアルロン酸の断片化に対する植物抽出液の抑制作用

抄録

Hyaluronic acid, a dermal component, depolymerization by superoxide and UV irradiation is considered as one way of skin-aging process. In this study, we screened plant extracts to find effective materials on inhibiting this depolymerization. Ascorbic acid-Fe system and UVA irradiation were used to generate superoxide. In result, Myrica rubra, Rhus chinensis, and Poeonia albiflora strongly inhibited the depolymerization in the Ascorbic acid-Fe system. On irradiating UVA, Myrica rubra and Rhus chinensis inhibited the depolymerization, Coptis chinensis also inhibited the depolymerization by UVA because of its absorption in UVA range, however it weakly inhibited the depolymerization in the Ascorbic acid-Fe system.
In conclusion, since these plant extracts will inhibit hyaluronic acid depolymerization by superoxide, they can be expected to apply to cosmetics.