抄録
In order to discover the antimicrobial activity against skin resident microorganisms responsible for axillary odor, the minimum inhibitory concentrations (MICs) of common fragrance materials were determined by agar plate dilution method.
In this assay, Corynebacterium minutissimum (CM), Arthrobacter sp., (LT), Staphylococcus aureus (SA), Staphylococcus epidermidis var. (SE) and Escherichia coli (EC) were tested.
Twelve musk chemicals were active against LT. Particularly, the MICs of ethylene brassylate and 5-α-androst-16-en-3-ol were both 12.5ppm. Also, nine sandal chemicals were active against CM, LT, and SA. Among them, the MICs of derivatives of camphorenic aldehyde were 50, 25 and 50ppm against CM, LT and SA respectively. But the MIC of its derivative against SE which dose not generate axillary odor was 2000ppm. Considering the fact that the MICs of fragrance materials ranged from 1000 to 2000ppm against common bacteria, musk and sandal chemicals are by far more effective against aerobic diphtheroids responsible for axillary odor.
