Clinical Application of a Model Predictive Intravenous Anesthesia Control System

Abstract

During surgical operation, patients must be kept under appropriate sedation. In order to keep patients under appropriate sedation, we developed an intravenous anesthesia control system using a model predictive controller, which uses propofol as the anesthetic drug and Bispectral Index (BIS) as the index of sedation, and has an identification function of the individual response of each patient. To make clinical applications, we have added a fail-safe function to this system for preventing drug over-infusion or intra-operative arousal. With the permission by the ethical committee of Kyoto University Hospital, 12 clinical applications were made from December 2001. In this paper, we report the fail-safe function and the result of clinical applications.