Blood glucose control system using a state predictive controller with an auto-tuning function

Abstract

Blood glucose control systemds using a state-predictive controller have been developed to control patient's blood glucose level properly after surgical operations. However, the performance of them on the overshoot and the settling time was not enough in animal experiments. This might be because the time variability of response of blood glucose to insulin infusion did not appropriately considered. In order to cope with it, an auto-tuning function using an online developed system is evaluated by simulations and animal experiments.