妊娠ラットに経口投与した n-butyltin 化合物の胚移行

抄録

Di-n-butyltin compounds have been shown previously to cause malformations such as cleft mandible, ankyloglossia and fused ribs in rat fetuses and to be transferred to embryos after oral treatment of dams on day 8 of gestation. In this study, embryonic transfer of tri-, di- and mono-n-butyltin administered to rats on day 8 of gestation were investigated. Tri-n-butyltin was detected together with its metabolites in embryos, maternal liver and blood 24hr after oral treatment with tri-n-butyltin acetate at 62.7μmol/kg on day 8 of gestation. Di-n-butyltin was also detected together with its metabolite in embryos, maternal liver and blood after treatment with di-n-butyltin diacetate (62.7μmol/kg). A very low concentration of mono-n-butyltin was detected in embryos, maternal liver and blood after treatment with mono-n-butyltin trichloride (62.7 or 1420μmol/kg). From these results, it is clear that tri- and di-n-butyltin compounds given to pregnant rats can be absorbed from the intestine and then transferred to embryos, but that the intestinal absorption of mono-n-butyltin is less.