Pathological examination and measurements of PCB and organochlorin pesticide residues were made in 18 wild ducks suffering from a disease which took a disastrous toll among waterfowl in the metropolitan area and was thought to be type C botulism. The most conspicous pathological changes observed in these sample ducks were enlargement of the liver, hyperaemia and/or atony in such organs as the small intestine, large intestine and rectum. No such pathological changes were detectable in the ducks caught by shotgun in the suburbs of Abashiri City, Hokkaido, and used as a control. The levels of total BHC, total DDT and PCBs in the sick ducks on a wet tissue basis were within the ranges of trace to 0.190ppm, 0.004 to 0.930ppm and 0.06 to 5.70ppm respectively. These levels were higher than those found in the control ducks. From the toxicological point of view, it can be said that PCB and pesticide residues in the sick ducks were so small that these substances did not participate directly in the cause of the disease.