In recent years, "Senior's heat stroke in houses" is increasingly gaining attentions. Indoor thermal environment is effected by performance of residential thermal insulation. Indoor thermal environment influence human physiology and a rapid rise in body temperature may cause heat stroke. Therefore, it is necessary to reduce the heat stroke by improving residential thermal insulation. In this study, authors have developed body temperature simulation model for senior people to take effective actions against indoor heat stroke. Furthermore, authors have predicted body temperature change and crisis rate of heat stroke in houses by using the body temperature simulation model for senior people.