5 ラット局所脳虚血病変への脳静脈還流障害の影響 (第443回 大阪歯科学会例会)

抄録

I evalvated the effect of the cerebral venous return impairment in rats on the progression of ischemic lesions and cerebral edema in the acute period of focal cerebral ischemia. I prepared a model of focal cerebral ischemia by obstruction of the right common carotid artery and middle cerebral artery, and studied changes in the cerebral tissue oxygen pressure and regional cerebral blood flow during ischemia and reperfusion. The severity of cerebral edema was evaluated by measuring the specific gravity and water content of the carebral tissue. The results suggested that increase in the cerebral water content was due to an increase in the gradient of the static hydraulic pressure between the ischemic foci and surrounding tissues, and progression of cerebral ischemia. These observations underline the importance of cerebral venous pressure in ischemic cerebrovascular disorders.