2016 年 64 巻 5 号 p. 247-252
A 69-year-old man was referred to our hospital because of occasional nosebleeds over a period of 6 months. Physical examinations were unremarkable except for anemia. Laboratory findings on admission indicated a hemoglobin level of 7.8g/dL. Magnetic resonance imaging revealed a mass occupying the right nasal cavity and infiltrating the bones of the paranasal sinus. Histological findings revealed olfactory neuroblastoma (esthesioneuroblastoma) and the disease was diagnosed to be at a locally inoperable advanced stage. Concurrent chemoradiotherapy (cisplatin plus etoposide and 60 Gy in 30 fractions of 2.0 Gy) was performed. Chemoradiotherapy failed to show significant tumor size reduction, but the nosebleeds stopped. The patient remains disease-free over 3 years after treatment. Although olfactory neuroblastoma is an extremely rare nasal tumor, we should be aware of the disease as a potential cause of nasal bleeding and anemia
