2008 Volume 49 Issue 6 Pages 381-389
A rapid multiresidue method was developed for determination of 98 veterinary drugs in livestock products and fish by LC/MS/MS. The drugs were extracted with methanol, and the extracted solution was diluted with water. The methanol concentration was adjusted to 50%, and finally the diluted solution was filtered through a microfiltration membrane (0.02 μm diameter pore size) prior to LC/MS/MS. Recoveries of 87 drugs from 4 foods (milk, egg, rainbow trout and cattle muscle) fortified at 0.2 μg/g were in the range of 50-150% with a coefficient of variation (%) of less than 20%. The values obtained by this method from livestock products containing antibiotics were similar to those obtained by the official methods. This proposed method is expected to be useful as a multiresidue analysis method for screening of veterinary drugs in livestock products and fish.
