Abstract
Rats were fed with a diet containing 100ppm of γ-BHC and sacrificed at regular intervals to determine resultant deposition of γ-BHC in their tissues.
There was a slight decrease in body weight of the experimental animals after they were maintained on the test diet for a period of five days. A loss of body weight by about one-half was found after the animals were placed on the diet for 56 days. There were no noticeable changes in the weight of the organs examined after 14 days of feeding with the test diet, except the liver in which a slight increase was seen.
Most organs examined showed the deposition in varying degrees of the chemical used for the experiment, especially in their fat tissues. The concentrations of the deposited chemical in various organs were found to reach their respective equilibrium levels in three to seven days and to keep the levels constant thereafter.
The equilibrium levels, per gram of fat, in various organs were almost the same and the values averaged 140-160μg/g. The liver and brain, however, showed considerably low values; the former 55μg/g and the latter 65μg/g.
