Abstract
Sodium carboxymethylstarch (Na-CMS) labeled on the position of 2-C carboxymethyl group was prepared, and its 2% aqueous solution was administered to the rat by gastric intubation, and the resultant radioactivity of the solution was estimated at 0.8Ci/ml.
The author found that 5.6% of the radioactivity was expired as CO2 within 96 hours, 1.8% excreted into the urine and 83% found in the faeces.
The urine was tested by thin layer chromatography using cellulose powder as adsorbent. As the result, three bands were conspicuous to some extent than the others. The first band, which was regarded as Na-CMS contaminated with faeces, was found on the starting line, the second band at the point of the Rf value 0.37 regarded as glucose derivative, and the third band at the point of the Rf 0.67 whose entity was not known.
Na-CMS in the faeces was determined with 2, 7-dihydroxynaphthalene, which was 79.1% of the dosage administered.
