Hygienic Study on Packaging and Vessel Made of Synthetic Resin (III)

Effects of Urea Compounds on the Toxicity of Formaldehyde

Abstract

Effects of urea, monomethylolurea (MMU) and dimethylolurea (DMU) on the toxicity of formaldehyde (HCHO) were investigated.
The LD₅₀ values of HCHO varied when mice were pretreated with urea, MMU or DMU. Mice pretreated with these chemicals were more susceptible to the toxic effect of HCHO than the control.
Blood uric acid level was significantly increased by subcutaneous injection of HCHO in dogs pretreated with urea, though no significant change was observed in the control.
Furthermore, increases of blood urea-nitrogen and creatinine levels in blood and of LDH activity were caused by HCHO in dogs, and these changes were significant after pretreatment with urea.