Abstract
Solutions of 54MnCl2 (0.5mg manganese chloride/kg, low dose; 10mg manganese chloride/kg, high dose) were intravenously injected to groups of pregnant rats on the 10th, 13th, 17th and 19th days of gestation, and the manganese distribution in maternal and fetal tissues were examined 3 hours after each injection and on the 20th day of gestation.
Three hours after the injection, placental distribution of the metal was predominantly higher in the 19th and the 17th days treated groups than in the 13th and the 10th days groups. However, the difference related to the stage of gestation was not evident concerning the manganese distribution in other maternal organs. The stage-linked difference of manganese distribution was also not recognized in fetal whole body.
The distribution pattern of the metal in the whole body of pregnant rats at the 20th day of gestation showed rather rapid decrease in the high dose group than in the low dose group. In maternal brain, bone and ovary of both dose groups, accumulation and/or slow elimination of manganese was observed. In all of the fetal organs of both dose groups, the earlier the stage of administration, the lower the distribution of manganese was observed, and, as compared with the maternal organs, remarkably higher concentrations of the metal were detected in fetal brain, heart, lung, liver and bone in the groups treated after the 13th day of gestation.
