Residues of Clopidol (3, 5-Dichloro-2, 6-dimethyl-4-pyridinol) in Tissues and Eggs of Chickens

Studies on Residues of Synthetic Antibacterials in Livestock Products. IV

Abstract

Residues of clopidol (3, 5-dichloro-2, 6-dimethyl-4-pyridinol) in chicken tissues and eggs were studied. Clopidol isolated from various tissues was determined by gas chromatography. Chickens of 10 weeks of age were given feed containing 250, 375 and 750ppm of clopidol for 10 days before laying eggs. The average contents of clopidol in the eggs were 6ppm, 10ppm and 19ppm, respectively. The concentration ratio (clopidol in whole egg/clopidol in feed ×100) of clopidol was found to be 2.64% on average, and clopidol in the egg disappeared within approximately one week.
In other experiment, chickens of 4 weeks of age were given clopidol-containing feed (250, 375 and 750ppm) for 8 weeks. High concentrations of clopidol were found in the liver, blood and kidneys as compared with the breast, thigh muscle and fat. After cessation of medication, the clopidol concentration in each tissue fell below 0.1ppm within 3 days.