Abstract
Propyl gallate (100mg per rat) was given by stomach tube to fed or fasted rats, and the urinary metabolites were determined by the iatroscan method. Most metabolites were excreted within 3 days after the administration.
The urine of fed rats contained the following metabolites (% of dose; mean of 5 rats): glucuronide of propyl gallate 5%, free gallic acid 7% and its conjugate 22%, free 4-O-methyl gallate 28% and its conjugate 10%. Free propyl gallate and resorcinol were not detectable in the urine, but pyrogallol was observed in 3 of 5 rats.
The amounts of total gallate, total 4-O-methyl gallate and glucuronide of propyl gallate excreted in the fasted rats were similar to those in the fed rats, but the formation of gallic acid conjugate was depressed to about 2/5 by fasting. Pyrogallol and resorcinol were observed in the urine of 4 of 5 fed rats and 1 of 5 fasted rats.
