Abstract
The tissue distribution and excretion of an insecticide synergist, piperonyl butoxide (PB), after oral and intravenous administration in male rats were investigated by the use of gas chromatography. After the oral administration of PB (250mg/kg), 2.35% of the dose was excreted in feces, whereas none was detected in the 48hr urine. Maximum plasma concentration of PB was attained 5hr after the administration, and the PB concentrations in brain, testis, liver and adipose tissue were higher than the plasma concentration at that time, Some PB remained in the plasma but none remained in the liver, brain and kidney 24hr after the administration; however, the accumulation of PB in the adipose tissue was remarkable and PB was observed even after 96hr.
After the intravenous administration of PB (250mg/kg), PB concentrations in the tissues were higher than those after the oral administration except in the liver, and the amount of PB in the lung was very large, being much higher than that in the adipose tissue.
