Experimental Studies on Toxicity of Tropolone (II)

Effects of Subacute Administration of Tropolone Sodium

Abstract

Subacute administration of Tropolone-Na was performed on dd-strain mice and Wistarstrain rats, and the following results were obtained.
1) The maximal tolerance dose to a mouse is presumed to be 48mg/kg or over.
2) The minimal toxic dose to a mouse is 26-48mg/kg.
3) The histological changes are most significant in the liver and kidneys in mice.
4) The maximal tolerance dose to a rat is presumed to be 36mg/kg or over.
5) The minimal toxic dose to a rat is 18-36mg/kg.
6) The histological changes, though mild, are seen most frequently in the liver and kidneys in rats.
7) When Tropolone-Na is used to maintain freshness of fishery products, it is regarded to be perfectly safe to men. It is, however, not always safe when for boiled fishpaste.