悪性黒色腫の5-S-Cysteinyldopaによる診断
1995 年 10 巻 1 号 p. 9-19
詳細
1995 年 10 巻 1 号 p. 9-19
Diagnosis of Malignant Melanoma by 5-S-Cysteinyldopa
We have developed a new diagnostic method for malignant melanoma by histo-chemical demonstration and chemical assay of 5-S-cysteinyldopa (5-S-CD) which is a main intermediate product of melanin metabolism. The diagnostic process for the primary lesion of malignant melanoma being performed at our department is as follows:
1. The stage is estimated by measuring urinary 5-S-CD value. 2. As a preoperative diagnostic method if it is an ulcerative lesion, touch-fluorescence method from the surface of the lesion and 5-S-CD value in the exudate in the gauze are made and if it is a non-ulcerative lesion, fine needle aspiration fluorescence method is used. 3. As a quick diagnostic method during operation touch-fluorescence method from the section of the lesion and measurement of 5-S-CD value in the lesion are made. 4. Decision of the morbid type is made from the fluorescence findings from the formalin-fixed and paraffin-embedded unstained specimen. 5. As a tumor marker, measurements are made of urinary and hematic 5-S-CD value with time.
