遺伝子治療―悪性黒色腫に対する臨床応用―

抄録

In this study, I review the newest and attractive technique for the treatment of metastatic melanoma, that is, gene therapy. First, the contents of guide line for gene therapy in Japan was described. Second, the background of gene therapy, for exam ple, the way of gene transfer and advantages and disadvantages of viral vectors and/or nonviral vectors were described. Third, the current status of melanoma gene therapy in USA was described; that is, retroviralmediated gene transduction and/or direct gene transfer with liposome is safe, and feasible gene transductions and treatment with IL-2/TNF and/or HLA B7 gene into TIL and/or melanoma cells are being carried out in USA. Further improvement of efficacy of gene transduction is needed and longterm follow up of patients should be done for safety.