A case of leiomyosarcoma in a 24-year-old female is reported. A red nodule was noticed on her right palm 10 years ago. After simple resections ulcer formations were developed repeatedly.
Histopathological examination revealed a mass of tumor cells with ulcer formation in the dermis to muscular layer. Tumor cells with eosinophilic cytoplasm were spindleshaped or epithelioid. Their nuclei were atypical and occasionally contained mitotic figures. Tumor cells were stained red with Azan-Mallory and Masson's trichrome. A boxed-in appearance was noted with silverstaining. Immunohistochemically, keratin, epithelial membrane antigen, vimentin, desmin and α-smooth muscle actin were positive in both spindle-shaped and epithelioid cells. The patient underwent amputa-tion of the right hand, because the diagnosis of leiomyosarcoma was established histologically.
