抄録
A 74-year-old-male double cancer case of malignant hemangioendothelioma (MHE) and gastric mucinous adenocarcinoma was reported. Several months after he got a bruise on his head, he developed erythematous Iesions and hemorrhargic tumors on the parietal and the left occipital scalp around the bruised area. Histological examinations showed that the tumor cells priliferated in the dermis with marked extravasation and formed numerous tubular structures including red blood cells, indicating that the tumor was MHE. General examinations also revealed the multiple metastatic lesions in liver, stomach, and thoracic vertebrae. He was treated with intralesional and intra-veinal injections of recomdinant interleukin-2 (rIL-2). Though the activities of natural killer cells and lymphokine activated killer cells were increased during the rIL-2 treatments, the size of the scalp tumors rapidly increased and disseminated intravenous coagulations was odserved in the patient to be resulted in death. Autopsy examinations showed numerous metastatic lesions of MHE in lung, intestine, liver, spleen, mesentery, posterior peritoneum, and bone mallow. The histological examinations on the autopsy spiecemens revealed that both the primary and all metastatic iesions were composed of extensive necrotic tissues, but adenocarcinoma was not necrotic, suggesting that these necrotic degenerations of the MHE tumor masses were presumably induced by the applications of rIL-2.
