左下肢の発赤と腫脹を主訴に来院した進行期乳房外Paget癌の1例
2002 年 17 巻 3 号 p. 234-237
詳細
2002 年 17 巻 3 号 p. 234-237
A 78-year-old female visited our hospital, representing a swollen left leg with erythema. Physical examination revealed an 8×5××2cm in diameter on the left labia majus and minus pudendi, and a 3×2×1cm in diameter on the right labium minus pudendi. The histological findings of a biopsy specimen from these tumors showed a mass of Paget cells with deep dermal invasion. These were positive for immunohistochemical staining PAS, anti-CEA and CK7, but negative for CK20. Furthermore, the erythema lesion from the left leg revealed the lymph duct's ectasis containing the mass of aggregated Paget cells. The clinical appearance and histochemical findings of reddish and swollen lesions seen in this patient might be one of the characteristics of metastasis and infiltration of Paget's cells to the lymph duct. We diagnosed the condition as extramammary Paget's carcinoma (T4N2M1).We tried operation and low dose FP therapy. The redness and swelling in the leg was gradually decreased by the low dose FP therapy. The patient died about 5 months after visiting our hospital, but we conclude that the low dose FP therapy is worth trying against the inflammation of metastatic Paget's carcinoma of the lymph duct. [Skin Cancer (Japan) 2002; 17: 234-237]
