Abstract
Pathological findings of extramammary Paget's disease will be discussed. Extramammary Paget's disease is a usually non-invasive adenocarcinoma of the skin outside of the mammary gland, and is characterized by 1) glandular formation, 2) intracytoplasmic mucin production, 3) hyperchromatic nuclei and 4) conspicuous nucleoli. Melanin pigmentation is rarely seen in the cytoplasm of Paget's cells. To detect Paget's cells, application of CAM 5.2 and CEA is useful. In evaluating the invasion one should be very careful not to over diagnose the tangential section or the in situ spread along the adnexal tissues. Finally we mention Toker cells as a precursor of extramammary Paget's disease. [Skin Cancer (Japan) 2008; 23: 320-331]
