Clinical Effects of the Cosmetic Moisturizer for Senile Xerotic Skin

Abstract

Objective :We subjectively and objectively analyzed the clinical effect of a cosmetic moisturizer for senile xerotic skin. Methods :We performed a clinical trial for 30 patients aged 60 years or older who visited Osaka University Hospital with senile xerotic skin between February and April 2017 using the moisturizing cream (NOV^○R skin cream D) supplied by Tokiwa Pharmaceutical Co. Ltd. The experimental control used was vaseline. We evaluated the skin lesions (drying, erythema,scales, scratching scars, lichenication), visual analogue scale (VAS) of itching, the stratum corneum water content, the transepidermal water loss (TEWL), the current perception threshold, and did stratum corneum analysis by immunouorescence staining on week 0 and 4 after starting the moisturizer application. Results :All skin lesions and itch VAS were signicantly decreased at week 4 following application of both vaseline and the moisturizing cream. The stratum corneum water content was signicantly increased at week 4 on application of both vaseline and the moisturizing cream, and the moisturizing cream was signicantly more effective compared to the vaseline. TEWL were signicantly decreased at week 4 on application of the moisturizing cream. Current perception thresholds following electrical stimuli at frequencies of 250 and 5 Hz were signicantly higher at week 4 with application of the moisturizing cream compared to the vaseline. Furthermore, SH-based uorescence intensity and the degree of multilayer exfoliation on stratum corneum cells were signicantly decreased at week 4 with application of the moisturizing cream. Discussion and Conclusion :In this study, the moisturizing cream equally improved the skin lesions and itch VAS, and signicantly improved the barrier function and stratum corneum function compared to the vaseline. Therefore, we consider that cosmetic moisturizers such as NOV skin cream D ^○R are useful for the treatment of xerotic skin in a similar manner to medical moisturizers. Skin Research, 17 : 274-283, 2018