Abstract
We describe a 17-year-old male with median raphe cyst of the penis. He had noticed a cyst on the penis about a year before and was seen in our out patient-clinic. A cyst located on the raphe of penis that was present along the coronary groove. Histopathological findings showed that cells of the cystic wall were consisted of stratified columnar epithelium and partly had decapitation secretion. In immunohistochemical studies, cells of the cystic wall were positive for carcino embryonic antigen, and negative for pan-keratin, α-smooth muscle actin, epithelial membrane antigen, and gross cystic disease fluid protein-15, indicating the cyst not to be derived from the apocrine gland.