Abstract
The patient was a 65-year-old woman, who had undergone total hysterectomy for cervical squamous cell carcinoma 27 years before. She first noticed a rice size papule on the vulva at the age of 62 years. The lesion gradually expanded, and when she consulted our hospital, it was an erythematous and flatly elevated plaque with infiltration, involving the labia major, labia minor, perineum, circumanal region, vestibule and vaginal wall. Histological examination revealed acanthosis with bud-like elongation and club-like thickning of rete ridges. Throughout the epidermis, many keratinocytes were highly atypical, and abnormal mitoses and dyskeratotic cells were also found, but the basement membrane remained intact. It was diagnosed as Bowen’s disease. The tumor was excised and replaced by a cutaneous muscle flap. HPV16 DNA was detected in DNA samples extracted from the tumor cells that rubbed off the vaginal wall of the resected tissue.
We also attempted to detect HPV DNA in the resected tissue of the cervical cancer, but none was found.
