Abstract
We reported a 54-year-old woman with epidermodysplasia verruciformis(EV). The relationship of her parents is cousinage. Multiple erythematous or brown scaling macules and plaques were scattered over her body since her childhood. She was operated for squamous cell carcinoma on left auricle in 1995. Since then, she had had operation for skin tumors 15 times until July 2001. Histopathologically, those tumors were diagnosed as basal cell carcinoma, squamous cell carcinoma, Bowen’s disease, and seborrheic keratosis respectively, and those were supposed to have supervened on EV.
She visited our hospital again in August 2004, because of a recurrence of Bowen’s disease on her left forearm, an appearance of a plaque with hyperkeratosis on her left cheek, and multiple black nodules on her trunk. Histopathologically, they were diagnosed with Bowen’s disease, actinic keratosis and basal cell carcinoma, respectively. HPV type 15 was detected in Bowen’s disease and actinic keratosis.
