Abstract
We report two patients with Muir-Torre syndrome. The first case was a 72-year-old woman, who had past histories of uterine body cancer, colon cancer, ureteral cancer and basal cell carcinoma. She was noticed a nodular lesion on her back, which was histologically diagnosed as sebaceous carcinoma. In addition, she had multiple sebaceous adenomas on the trunk and forehead. The second patient was a 63-year-old man who had been followed up for an advanced stage of esophageal cancer. He developed a papule on his nose, which was progressively enlarged. Histologically, the tumor exhibited typical characteristics of sebaceous carcinoma. Because of having visceral malignancies and sebaceous carcinoma in combination, the two cases were diagnosed as Muir-Torre syndrome. In addition, our survey of the records of the past patients in our department revealed that 2 of 4 patients with sebaceous carcinoma had visceral malignancies, indicative of Muir-Torre syndrome.
