抄録
Voxel based morphometry (VBM) is an approach which extracts voxels whose brain tissue density is statistically different from control groups using magnetic resonance (MR) images. It has been applied to diagnose cerebral disorders, cognitive dementias, etc. However, VBM is not applied to neonatal brains because of large differences between the adult brain and the neonatal brain. This article proposes a modified VBM for neonatal brain. The modified VBM segments the brain region by using skull stripping method for neonates, and normalizes the segmented brain into the standardized neonatal brain. The standardized neonatal brain is constructed by using non rigid image registration. The proposed method was applied to 12 neonates whose age was between 0 weeks 30 weeks. For any neonates, the method normalized the brain shape successfully.
