Do Fasudil and Losartan Treatments Improve EDH Mediated Coronary Dilation in Hypertensive Insulin Resistant Rats through Gap Junctions

James T. Pearson; Hirotsugu Tsuchimochi; Takashi Sonobe; Vijayakumar Sukumaran; Tadakatsu Inagaki; Keiji Umetani

doi:10.18957/rr.12.6.358

Section A

Do Fasudil and Losartan Treatments Improve EDH Mediated Coronary Dilation in Hypertensive Insulin Resistant Rats through Gap Junctions

James T. Pearson, Hirotsugu Tsuchimochi, Takashi Sonobe, Vijayakumar Sukumaran, Tadakatsu Inagaki, Keiji Umetani

著者情報

キーワード: coronary function, microvessels, gap junctions, diabetes, 2016B1064, BL28B2

ジャーナルオープンアクセス

2024 年 12 巻 6 号 p. 358-362

DOI https://doi.org/10.18957/rr.12.6.358

詳細

抄録

　We investigated in hypertensive diabetic rats the contributions of endothelium derived hyperpolarization (EDH) and nitric oxide to the maintenance of coronary perfusion and conduction of vasodilation to distal microvessels utilizing synchrotron microangiography. We found that both fasudil and combined fasudil-losartan treatment improved EDH and nitric oxide mediated microvessel dilation.

責任著者(Corresponding author)

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