A Role for GRK2 in the Development of Right Ventricular Failure in Pulmonary Arterial Hypertension

Mark T. Waddingham; Takashi Sonobe; Hirotsugu Tsuchimochi; Ryotaro Asano; Mikiyasu Shirai; Takeshi Ogo; James T. Pearson

doi:10.18957/rr.13.4.189

Section A

A Role for GRK2 in the Development of Right Ventricular Failure in Pulmonary Arterial Hypertension

Mark T. Waddingham, Takashi Sonobe, Hirotsugu Tsuchimochi, Ryotaro Asano, Mikiyasu Shirai, Takeshi Ogo, James T. Pearson

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Keywords: Pulmonary Arterial Hypertension, Right Ventricle, Myocardium, Cross-Bridges, GRK2, 2019B1160, BL40XU

JOURNAL OPEN ACCESS

2025 Volume 13 Issue 4 Pages 189-195

DOI https://doi.org/10.18957/rr.13.4.189

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Abstract

　We investigated if GRK2 was involved in RV failure in a rat model of PAH. We utilized SAXS in the in situ beating heart at BL40XU to establish if GRK2 inhibition with paroxetine could prevent changes in myosin mass transfer to actin. Despite high mortality in PAH rats, our findings revealed that paroxetine-induced changes in myosin mass transfer that correlated with improved RV function.

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