[in Japanese]

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　This study determined the extent that right coronary endothelial dysfunction develops in early pulmonary arterial hypertension (PAH) rats and if dysfunction is accelerated by insulin resistance. Exacerbated coronary endothelial dysfunction developed in diabetic rats during the transition to PAH and was associated with increased thrombosis and reduced right ventricle contractility.

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　We investigated whether Liraglutide can prevent pulmonary microvessel dysfunction in pulmonary hypertensive rats. We showed that insulin resistance drives endothelial cell-smooth muscle dysfunction during through remodeling and diminished nitric oxide-mediated dilation and increased rho-kinase mediated constriction, and that Liraglutide largely prevents these changes with early intervention.

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[in Japanese]

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[in Japanese]

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　This study aimed to investigate how small organic molecules such as amino acids interact with and potentially alter the structure of liquid water. Using X-ray Raman Spectroscopy (XRS) at beamline BL12XU of SPring-8, we measured a series of aqueous proline solutions at varying concentrations, alongside pure water as a reference. The goal was to observe changes in the oxygen K-edge spectral features as a function of solute concentration, which could indicate perturbations in the hydrogen-bonding network of water. However, the spectra obtained did not reveal statistically significant differences between the samples due to limited signal-to-noise ratio and experimental sensitivity. This report documents the initial results from SPring-8 and outlines the scientific rationale for further investigation.

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[in Japanese]

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　In this work, we will study the role of hydrogen bonds on the PDA biosensor by taking FTIR spectra while changing the humidity. The PDA has the carboxyl head groups forming the hydrogen bonding between head groups before exposure to moisture, which can make the PDA linear. When increasing the humidity, the water molecules may cut these hydrogen bondings, which may allow PDA side chains easier to twist and change color. This is the hypothesis we have and want to test it in this experiment.

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[in Japanese]

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