Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats

Patrick Meagher; Yi Ching Chen; Hirotsugu Tsuchimochi; Lucinda M. Hilliard; Katrina M. Colafella; Keiji Umetani; Mikiyasu Shirai; Robert E. Widdop; Kate Denton; James T. Pearson

doi:10.18957/rr.8.3.473

Section A

Renin-Angiotensin System Role in the Pathophysiological Progression of Coronary Dysfunction in Prediabetic Female Rats

Patrick Meagher, Yi Ching Chen, Hirotsugu Tsuchimochi, Lucinda M. Hilliard, Katrina M. Colafella, Keiji Umetani, Mikiyasu Shirai, Robert E. Widdop, Kate Denton, James T. Pearson

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Keywords: angiotensin-II receptors, vasodilation, endothelium, diabetes, 2014B1154, BL28B2

JOURNAL OPEN ACCESS

2020 Volume 8 Issue 3 Pages 473-475

DOI https://doi.org/10.18957/rr.8.3.473

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Abstract

We investigated in female rats the coronary response to infusion of angiotensin-II type 2 receptor agonist compound 21 (C21) utilizing high resolution SR microangiography. We found that in non-diabetic rats acute C21 infusion evoked dilation in the coronary microvessels that most likely involved endothelium derived hyperpolarization factors, while C21 evoked mild constriction in prediabetic rats.

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