Abstract
The saccharides on the cell surfaces have the bio-signals in the life phenomena, and the biomaterials with molecular recognition abilities were fabricated based on the saccharide. The bio-materials with large molecular recognition abilities were fabricated by the saccharide assembly, which amplified the molecular recognition abilities by the multivalency. The glyco-conjugates with thin layer, nanoparticles and polymers were designed. The glyco-conjugates had the optical and electrochemical functionalities, which were used for the biosensing of proteins and pathogens. We have prepared the glyco-thin layer, which could detect Shiga toxins and amyloid beta peptides. We also prepared the glyco-substrates and glyco-nanoparticles via RAFT living radical polymerization, which showed the high specificity to proteins. Moreover, the glyco-dendrimer with dendrimer showed that the glyco-conjugate could control the protein amyloidosis and cytotoxicity.
