Abstract
The surface properties of biomaterials, including chemical composition, nano- or microstructured morphology, wettability, elasticity and electrostatic property, are very important for manipulation of stem cell functions such as adhesion, proliferation and differentiation. Photoreactive polyallylamine, poly （acrylic acid）, poly （ethylene glycol） and poly （vinyl alcohol） were grafted or micro-patterned onto cell culture polystyrene plates by UV irradiation. Human mesenchymal stem cells （MSC）, a promising cell source for regenerative medicine were cultured on the polymer-grafted or micropatterned plates to investigate the effect of functional groups on their chondrogenic, osteogenic, and adipogenic differentiation. The adhesion, proliferation, and differentiation of MSC could be manipulated by the polymer-grafted or micropatterned surfaces.
